The effects of these powerful supplements are dose-dependent.

At low doses (approximately 0.5 grams per day) they can activate gene transcription
factors (such as Nrf2) that increase the synthesis of anti-oxidative enzymes to reduce
oxidative stress.

At higher levels (approximately 1.5 grams per day) Polyphenols activate the SIRT1 gene
that increases the production of AMP kinase (AMPK) that controls cellular metabolism.

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