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Omega-3 Intake Reduces Cardiac Risks

Omega-3 Intake Reduces Cardiac Risks

Results from a new study published in the Journal of Clinical Lipidology showed that in 14 randomized, controlled trials (RCTs) of 71,899 people, consumption of EPA and DHA omega-3s reduced the risk of cardiac death by a statistically-significant average of 8 percent. Cardiac death accounts for about two-thirds (about 405,000) of all cardiovascular disease deaths in the United States, and 42 percent (7.4 million) globally, each year. This is the first published meta-analysis to include cardiac death (also known as “coronary mortality”) as a primary endpoint, and the most comprehensive review of the evidence to date.

The meta-analysis showed even greater—17 percent—risk reduction in groups who had elevated triglycerides or LDL cholesterol. These results are consistent with the hypothesis that EPA and DHA omega-3s may be most useful for reducing cardiac death in higher risk individuals (see table), which is important since The National Center for Health Statistics estimates that 25 percent of adults in the US have triglyceride levels ≥150 mg/dL and 27 percent have LDL cholesterol levels ≥130 mg/dL (4). The greatest reduction in cardiac death rates—an almost 30% risk reduction—was observed in trials that utilized dosages of more than 1 gram of EPA and DHA per day.

The RCTs reviewed were longer than six months in length, and investigated cardiac death as the primary outcome, comparing frequencies of cardiac death events between the omega-3 and control groups. The researchers reviewed studies published through December 2016 that included both dietary supplement and pharmaceutical omega-3 interventions. In the omega-3 groups, 1,613 cardiac deaths were recorded (4.48 percent of subjects) compared to 1,746 cardiac deaths in the control groups (4.87 percent of subjects). This study did not review the effects of EPA and DHA consumption from fish on cardiac death risk because no randomized, controlled trials exist, but observational studies on EPA and DHA from fish also support a benefit in risk reduction.

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Reversal of Chronic Disease

Reversal of Chronic Disease

Anti-Inflammation nutrition is based on the concept that our food can alter the hormones
(eicosonoids & resolvins) as well as the expression of our genes, especially those that
control Inflammation Reversal of chronic disease to the fullest or at a level where you will
need a low amount of medication.

Inflammation Reversal can be achieved by:
1) Anti-Inflammatory diet
2) Adequate amount of high quality Omega-3 fatty acids
3) Adequate levels of Polyphenols

Application of all three, monitored by periodic blood test to check your Arachidonic acid
levels (AA/EPA) result in a powerful synergistic effect that controls cellular inflammation
for a lifetime.

Insulin and Leptin resistance are the primary drivers of excess body fat and early
development of chronic diseases such as diabetes and Alzheimers, hypertension, and
stroke.

Insulin and Leptin resistance are primarily caused by Inflammatory foods, gene
transcription factors are proteins in every cell that activate select portions of the DNA for
expression. The key gene transcription factor that controls inflammation is nuclear factor
Kappa B. This gene expression is significantly controlled by the food we eat.

Our genes cannot be changed, but their expression can. The expression of our gene is often
controlled by gene transcription factor that can be affected by both hormones and specific
nutrients. The hormone Insulin is one such key moderator and so are Polyphenols and
Omega-3 fatty acids.

The microbes in the gut are also essential in controlling inflammation. Adequate amounts
of ferment able fiber ( ie Prebiotic) coupled with Omega-3 and Polyphenols helps
tremendously.

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Markers of Inflammation

Markers of Inflammation

• AA/EPA ratio
• TG/HDL ratio
• HbA1C levels

• AA/EPA levels is the best clinical marker for the balance of Initiation and
Resolution of Inflammation. This was first demonstrated in 1989 in the New
England Journal of Medicine by a Harvard Medical School researcher.
The ideal ratio is 1.5 to 3 as found in the Japanese population. For comparison an
average American has a AA/EPA ratio of 18.

• TG/HDL ratio is a marker of Insulin resistance in the liver. The ideal ratio should
be less than 1 measured in mg/dl

• HbA1C level. This marker of long term oxidative stress. The ideal range is between
4.9 to 5.1%

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Why High-dose Polyphenols?

Why High-dose Polyphenols?

The effects of these powerful supplements are dose-dependent.

At low doses (approximately 0.5 grams per day) they can activate gene transcription
factors (such as Nrf2) that increase the synthesis of anti-oxidative enzymes to reduce
oxidative stress.

At higher levels (approximately 1.5 grams per day) Polyphenols activate the SIRT1 gene
that increases the production of AMP kinase (AMPK) that controls cellular metabolism.

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Why High-dose Omega-3 Fatty Acids?

Why High-dose Omega-3 Fatty Acids?

It is difficult to obtain adequate levels of Omega-3 fatty acids (EPA & DHA) from the
foods that we eat. These are the molecular building blocks that produce a specialized
group of hormones known as resolvins.

Resolvins are critical to the resolution of inflammation.

Without adequate levels of these Omega-3 fatty acids in the blood, it is impossible to make
adequate levels of resolvins to return the body back to equilibrium after the initiation of
inflammation.

It becomes a cellular battle if the initiation phase of inflammation is too strong or the
resolution phase is too weak the result is chronic cellular inflammation. The body simply
can not overcome the power struggle.

The good news is that this condition can be controlled.

The answer is taking the proper amount of high quality Omega-3 fish oil.

In order to achieve adequate levels of resolvin formation, a healthy person (one that is not
obese) will require a minimum of 2.5 grams per day of EPA & DHA. For those with an
existing chronic inflammatory disease, the levels of EPA & DHA required can be
considerably higher to increase the resolution of existing cellular inflammation.

This is why it is imperative that you have a doctor that knows what they are doing and can
order the proper blood test that will determine the dose that is right for you.

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