The effects of these powerful supplements are dose-dependent.
At low doses (approximately 0.5 grams per day) they can activate gene transcription
factors (such as Nrf2) that increase the synthesis of anti-oxidative enzymes to reduce
At higher levels (approximately 1.5 grams per day) Polyphenols activate the SIRT1 gene
that increases the production of AMP kinase (AMPK) that controls cellular metabolism.